Age-related differences in white matter microstructure measured by advanced diffusion MRI in healthy older adults at risk for Alzheimer’s disease
Year: 2022
Type: article
Study design: Observational Study
Abstract: Neurite orientation dispersion and density imaging (NODDI) is an advanced diffusion imaging technique, which can detect more distinct microstructural features compared to conventional Diffusion Tensor Imaging (DTI). NODDI allows the signal to be divided into multiple water compartments and derive measures for orientation dispersion index (ODI), neurite density index (NDI) and volume fraction of isotropic diffusion compartment (FISO). This study aimed to investigate which diffusion metric-fractional anisotropy (FA), mean diffusivity (MD), NDI, ODI, or FISO-is most influenced by aging and reflects cognitive function in a population of healthy older adults at risk for Alzheimer's disease (AD). Age was significantly associated with all but one diffusion parameters and regions of interest. NDI and MD in the cingulate region adjacent to the cingulate cortex showed a significant association with a composite measure of Executive Function and was proven to partially mediate the relationship between aging and Executive Function decline. These results suggest that both DTI and NODDI parameters are sensitive to age-related differences in white matter regions vulnerable to aging, particularly among older adults at risk for AD.
Source: Aging Brain
Authors: Alice Motovylyak, Nicholas M. Vogt, Nagesh Adluru, Yue Ma, Rui Wang, Jennifer M. Oh, Steven R. Kecskemeti, Andrew L. Alexander, Douglas C. Dean, Catherine L. Gallagher, Mark A. Sager, Bruce P. Hermann, Howard A. Rowley, Sterling C. Johnson, Sanjay Asthana, Barbara B. Bendlin, Ozioma C. Okonkwo
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,000
Funders: U.S. Department of Veterans Affairs, Alzheimer's Association, Helen Bader Foundation, Northwestern Mutual Foundation, Wisconsin Alumni Research Foundation, Extendicare Foundation, Northwestern University, National Institutes of Health, Geriatric Research Education and Clinical Center, National Institute on Aging, National Institute of Neurological Disorders and Stroke, National Center for Research Resources, NIH Clinical Center
Awards: G1417337112, G1496489604, G1912628505, G1922473590, Alzheimer's Disease Connectome Project, G2360966051, Institutional Clinical and Translational Science Award (UW-Madison)(UL1), G5406081316, Stroke Rehabilitation utilizing BCI technology, G5590718187, Gut Microbiome contributions to the development and progression of Alzheimer’s Disease, Algebraic Formulations for Characterizing Structural Brain Connectivity Changes and Pathology Transmission Networks in Preclinical Alzheimer's Disease, G631053645, G8859167876, G892867735, G9000007361, G9000026038, G9000033795, G9000037916, G9000042137, G9000071231, G9000092144, G9000115206, G9000152548, G9000165211, G9000194719, G9000208074, G9000208846, G9000212218, G9000256157, G9000283425, G9000291250, G9000352745, G9000355624
OpenAlex ID: W4210307149