Longitudinal Trajectories of Participant- and Study Partner-Rated Cognitive Decline, in Relation to Alzheimer’s Disease Biomarkers and Mood Symptoms
Year: 2022
Type: article
Study design: Observational Study
Abstract: Whereas discrepancies between participant- and study partner-reported cognitive concerns on the Alzheimer’s disease (AD) continuum have been observed, more needs to be known regarding the longitudinal trajectories of participant- vs. study partner-reported concerns, particularly their relationship to AD biomarkers and mood symptomology. Additionally, it is unclear whether years of in-clinic data collection are needed to observe relationships with AD biomarkers, or whether more frequent, remote assessments over shorter periods of time would suffice. This study primarily sought to examine the relationships between longitudinal trajectories of participant- and study partner-rated cognitive decline and baseline biomarker levels [i.e., amyloid and tau positron emission tomography (PET)], in addition to how mood symptomatology may alter these trajectories of concerns over a 2-year period. Baseline mood was associated with longitudinal participant-rated concerns, such that participants with elevated depression and anxiety scores at baseline had decreasing concerns about cognitive decline over time (fixed estimate = −0.17, 95% CI [−0.29 to −0.05], t = −2.75, df = 457, adj. p = 0.012). A significant interaction between baseline amyloid (fixed estimate = 4.07, 95% CI [1.13–7.01], t = 2.72, df = 353, adj. p = 0.026) and tau (fixed estimate = 3.50, 95% CI [0.95–6.06], t = 2.70, df = 331, adj. p = 0.030) levels was associated with increasing study partner concerns, but not participant concerns, over time. The interaction between amyloid and study partner concerns remained significant when utilizing only the first year of concern-related data collection. Overall, these results suggest that frequent, remote assessment of study partner-reported concerns may offer additional insight into the AD clinical spectrum, as study partners appear to more accurately update their concerns over time with regard to pathology, with these concerns less influenced by participants’ mood symptomatology.
Source: Frontiers in Aging Neuroscience
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
Funders: Alzheimer's Association, Harvard NeuroDiscovery Center, Massachusetts General Hospital, Centre d'Imagerie BioMédicale, National Institutes of Health, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, National Institute on Aging, National Institute of Biomedical Imaging and Bioengineering, National Center for Research Resources
Awards: Depressive symptoms in the pathogenesis of preclinical Alzheimer's Disease, G1185609304, G1220546045, Decoding neural systems underlying anosognosia for memory loss in aging and Alzheimer's disease, G1360098495, Characterizing the evolution of Subjective Cognitive Decline in preclinical Alzheimer's disease, G1778344677, Influence of Age-related Neuropathology on Functional Brain Networks, G1852383229, G1865263550, G1947016736, Sex, tau accumulation, and the role of menopause in AD pathogenesis, G2429896787, G2483948867, Depressive and anxiety symptoms and tau PET imaging in Alzheimer's disease, G3171611343, G3549079774, G393103480, Mentoring Imaging Research in Early AD, G5021443450, Examining the trajectory of Subjective Cognitive Decline in preclinical AD, Center for Functional Imaging Technologies, Sex differences in the progression of Alzheimer's disease: is menopause the key?, Disentangling the contribution of tau to aging and AD, Evolution of memory related fMRI activation over the course of MCI and AD, G653110949, G655563530, A Siemens MAGNETOTOM Trio 3 Tesla MRI System, Massachusetts Alzheimer's Disease Research Center, G7687018586, Center for Functional Imaging Technologies, G8273854460, G868551019, A Storage Area Network for Structural and Functional Image Analysis, G9000074708, G9000208643, Impact of Amyloid and Tau on the Aging Brain: The Harvard Aging Brain Study, Silicon Graphics Prism Extreme 128P/1TB
OpenAlex ID: W4210346179