Work

A Rare Presentation of Extraskeletal Osteosarcoma in the Arm

Year: 2021

Type: article

Abstract: Extraskeletal Osteosarcoma (ESOS) is a rare mesenchymal malignancy that commonly manifests in the fifth to seventh decade of life. It occurs frequently in the deep soft tissues of the lower extremities, in particular the thigh. These are aggressive tumours, showing local recurrence, and almost 90% show a distant metastasis in particular to the lung at the time of diagnosis, so it becomes crucial to diagnose these lesions at an early stage. Here, authors report a case of 56-year-old female, who presented with painless swelling of size 2×2 cm in the lateral aspect of the right arm. There was no history of prior trauma. On imaging studies, it was found to be a subcutaneous swelling with calcification and not attached to the nearby bone. Excision biopsy showed a malignant neoplastic lesion with osteoid surrounded by atypical cells with frequent mitosis, and with heterologous bone and cartilage formation. The diagnosis of ESOS was confirmed using special AT-rich sequence-Binding protein 2 (SAT-B2) immunohistochemistry. The case is presented here because of its rarity of occurrence in the arm, size and utilisation of SAT-B2 in confirming the diagnosis.

Source: JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

DOI: 10.7860/jcdr/2021/51614.15703

Authors: Rajeswari Thivya, Aarthi Kannan, K Priyadharshini Ganesh

Institutions: Chettinad Academy of Research and Education, Chettinad Health City

Language: English

Topic: Sarcoma Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $275