Year: 2022
Type: article
Abstract: Physical exercise—especially at high intensity—is known to impose cardiac stress, as mirrored by, e.g., increased blood levels of cardiac stress biomarkers such as cardiac Troponin T (cTnT) and NT-proBNP. We examined healthy young participants to determine whether a few nights of short sleep duration alter the effects of acute exercise on these blood biomarkers. Sixteen men participated in a randomized order in a crossover design, comprising three consecutive nights of a) normal sleep duration (NS, 8.5 h of sleep/night) and b) sleep restriction (SR, 4.25 h of sleep/night). Blood was repeatedly sampled for determination of NT-proBNP and cTnT serum levels before and after a high-intensity exercise protocol (i.e., 75% VO2maxReserve cycling on an ergometer). Under pre-exercise sedentary conditions, blood levels of cTnT and NT-proBNP did not significantly differ between the sleep conditions (P > 0.10). However, in response to exercise, the surge of circulating cTnT was significantly greater following SR than NS (+37–38% at 120–240 min post-exercise, P ≤ 0.05). While blood levels of NT-proBNP rose significantly in response to exercise, they did not differ between the sleep conditions. Recurrent sleep restriction may increase the cardiac stress response to acute high-intensity exercise in healthy young individuals. However, our findings must be further confirmed in women, older subjects and in patients with a history of heart disease.
Source: Molecular Metabolism
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,360
Funders: Swedish Cancer Foundation, Cancerfonden, Göran Gustafssons Stiftelse för Naturvetenskaplig och Medicinsk Forskning, Svenska Sällskapet för Medicinsk Forskning, Hjärnfonden, Novo Nordisk, Vetenskapsrådet, Magnus Bergvalls Stiftelse, Diabetesfonden, Novo Nordisk Fonden, Mats Klebergs Stiftelse, Novo Nordisk Foundation Center for Basic Metabolic Research, Insamlingsstiftelsen Diabetes Wellness Network Sverige
OpenAlex ID: W4210447373