Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus
Year: 2022
Type: article
Abstract: The influence of the microbiota on viral transmission and replication is well appreciated. However, its impact on retroviral pathogenesis outside of transmission/replication control remains unknown. Using murine leukemia virus (MuLV), we found that some commensal bacteria promoted the development of leukemia induced by this retrovirus. The promotion of leukemia development by commensals is due to suppression of the adaptive immune response through upregulation of several negative regulators of immunity. These negative regulators include Serpinb9b and Rnf128, which are associated with a poor prognosis of some spontaneous human cancers. Upregulation of Serpinb9b is mediated by sensing of bacteria by the NOD1/NOD2/RIPK2 pathway. This work describes a mechanism by which the microbiota enhances tumorigenesis within gut-distant organs and points at potential targets for cancer therapy.
Source: Cell Reports
Institutions: University of Chicago, Stanford University
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,200
Awards: G123948859, Molecular and Cellular Biology Training, G406168540, G4484399200, G5297356816, G7175603487, G7205445978, G7294357767, G7295898749, G9000012814, Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID), Cancer Center Support Grant, Virally-induced tumorigenesis controlled by the microbiota, Interdisciplinary Training Program in Immunology
OpenAlex ID: W4295903387