Work

Reply to Pandey: Possible functional impact of IgG3 allotype constant region

Year: 2022

Type: letter

Abstract: In a letter to the editor (1), Janardan Pandey comments on our recent study demonstrating that IgG3 switch variants of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specific antibody (Ab) are superior to other IgG subclasses in binding to the SARS-COV-2 spike protein (SP) in virus neutralization activity (2). Understanding the effect of individual IgG subclasses to modulate antigen (Ag) binding and activity of IgG Abs is an essential basis for interpreting polyclonal immune responses that occur in vivo. For example, strong IgG3 and IgG4 responses were identified in the sera of COVID-19 patients, which need to be … [↵][1]1To whom correspondence may be addressed. Email: herta.steinkellner{at}boku.ac.at. [1]: #xref-corresp-1-1

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.2120537119

Authors: Somanath Kallolimath, Falk Nimmerjahn, Herta Steinkellner

Institutions: BOKU University, Friedrich-Alexander-Universität Erlangen-Nürnberg

Language: English

Topic: SARS-CoV-2 and COVID-19 Research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Austrian Science Fund