Neuropathology of Late Life Depression: Clinical Predictors of Amyloid and Tau Neuropathology in Non-demented Older Adults with Depression
Year: 2021
Type: dissertation
Study design: Observational Study
Abstract: Previous studies regarding the relationship between late-life depression and Alzheimer’s amyloid and tau neuropathology have reported conflicting findings. This study is a cross-sectional post-mortem study of non-demented older adults in the 2005-2020 National Alzheimer’s Coordinating Center database (n=395; 94 Thal [spread of amyloid pathology beyond the neocortex], 393 Braak [spread of tau pathology], 394 CERAD [density of amyloid neuritic plaques]). Those who had recent depression (within previous 2 years) were more likely to have higher Thal phase compared to those without a history of depression (OR=13.3, p=0.019). Depression was not associated with CERAD or Braak scores. Sex or apolipoprotein-E did not moderate their associations. The relationship between late-life depression and Alzheimer’s neuropathology may be explained by spread of amyloid pathology beyond the neocortex to involve subcortical regions implicated in regulation of mood and motivated behaviour, which may be therapeutic targets for the prevention of Alzheimer’s dementia in this population.
Source: TSpace (University of Toronto)
Author: Kim, Doyoung
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4210732509