Elevated remnant cholesterol is closely associated with incident hypertension: a cohort-based study from China
Year: 2022
Type: preprint
Study design: Observational Study
Abstract: Background Remnant cholesterol (RC) has been confirmed to be associated with cardiovascular events. However, the association between RC and hypertension (HTN) has not been illustrated. Thus, this study aimed to investigate the association of RC with HTN and to compare the predictive values of RC, lipid parameters for the risk of incident HTN in a Chinese population. MethodsThis cohort study included 18483 participants, who are followed for the incidence of HTN. RC were divided into five groups: the < 20% group, the 20–39% group, the 40–59% group, the 60–79% group and the ≥ 80% group, according to quintile division of the participants. Cox proportional hazards models were used to evaluate the association between RC vs other lipid parameters and HTN.ResultsDuring a mean follow-up of 1.1 years, 525 (17.55%) HTN occurred. Multivariate Cox regression analysis shows that compared with conventional lipid parameters, RC remains significantly associated with HTN (hazard ratio (HR) 1.68, 95%confidence interval (CI) 1.40-2.01, p<0.0001). In a stratified analysis, RC is still significant predictive of developing HTN in the subgroups of young age (<55 years) (HR 1.74, 95%CI 1.40-2.16, p<0.0001), as well as with body mass index (BMI) <18.5 kg/m2(HR 2.87, 95%CI 1.30-6.37, p=0.0464) or BMI ≥ 28 kg/m2(HR 1.81, 95%CI 1.11-2.96, p=0.0179), and with fatty liver diseases (HR 1.66, 95%CI 1.17-2.36, p=0.0047).ConclusionsElevated RC is significantly associated with HTN and is a superior predictor for developing HTN independent of other risk factors, suggesting RC may be a new target of managing HTN.
Source: Research Square
Authors: Guang Wang, Jie Wang, Ying Wang, Yu An, Jia Liu, Song Leng
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4210743566