Work

The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments

Year: 2022

Type: review

Abstract: Obesity is associated with hypothalamic-pituitary-testicular axis dysregulation in males. Here, we summarize recent evidence derived from clinical trials and studies in preclinical animal models regarding the role of androgen receptor (AR) signaling in the pathophysiology of males with obesity. We also discuss therapeutic strategies targeting the AR for the treatment of obesity and their limitations and provide insight into the future research necessary to advance this field.

Source: Obesity Reviews

DOI: 10.1111/obr.13429

Authors: Varun S. Venkatesh, Mathis Grossmann, Jeffrey D. Zajac, Rachel A. Davey

Institutions: The University of Melbourne, Austin Health, Austin Hospital

Language: English

Topic: Hormonal and reproductive studies

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,800