Moderate Intensity Exercise in Pre-manifest Huntington's Disease: Results of a 6 months Trial.
Year: 2021
Type: article
Abstract: BACKGROUND: While it has been shown that aerobic exercise interventions are well tolerated in participants with the Huntington disease (HD) gene mutation, no study to date has tested whether an aerobic exercise intervention benefits brain structure and function in pre-manifest HD. OBJECTIVE: In this study we utilized magnetic resonance (MR) imaging techniques to assess the efficacy of moderate-to-vigorous exercise treatment relative to active stretching and toning control. METHODS: Forty pre-manifest participants with confirmed HD gene expansion were recruited into a two-arm intervention study that included a moderate-to-vigorous intensity home-based walking exercise intervention (N=34) and an active stretching and toning control intervention (N=6). Participants were assessed at baseline and after 26 weeks in one of the two study arms. RESULTS: max and change in brain structure. CONCLUSIONS: Though this study did not show efficacy for the exercise intervention, secondary results suggest that aerobic exercise interventions increasing cardiorespiratory fitness may be a potential way to slow progression in pre-manifest HD.
Source: PubMed
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: Neurobiological Predictors of Huntington's Disease, Statistical disease modeling and clinimetrics to prepare for preventive trials in huntington disease, University of Iowa - Research 3T MRI Connectome Upgrade, Preparing for preventive clinical trials in Huntington's disease, Statistical disease modeling and clinimetrics to prepare for preventive trials in huntington disease, Exercise Intervention for Slowing HD Progression, The University of Iowa Clinical and Translational Science Award, Preparing for preventive clinical trials in Huntington's disease
OpenAlex ID: W4210948485