Year: 2022
Type: review
Abstract: Elimination of dead or live cells take place in both a healthy and diseased central nervous system (CNS). Dying or dead cells are quickly cleared by phagocytosis for the maintenance of a healthy CNS or for recovery after injury. Live cells or parts thereof, such as the synapses and myelin, are appropriately eliminated by phagocytosis to maintain or refine neural networks during development and adulthood. Microglia, the specific population of resident macrophages in the CNS, are classically considered as primary phagocytes; however, astrocytes have also been highlighted as phagocytes in the last decade. Phagocytic targets and receptors are reported to be mostly common between astrocytes and microglia, which raises the question of how astrocytic phagocytosis differs from microglial phagocytosis, and how these two phagocytic systems cooperate. In this review, we address the consequences of astrocytic phagocytosis, particularly focusing on these elusive points.
Source: Glia
DOI: 10.1002/glia.24145
Institutions: Nagoya University, University of Yamanashi
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,800
Awards: 固有感覚異常を標的としたリハビリテーションによる脳内炎症緩和をめざす基礎研究, Roles of lipid signaling and remodeling in nerve injury, Development of manipulation methods of "microglia memory" and its application for brain function, G199310794, G2521286739, G2576085165, Mechanisms underlying retinal glia-mediated glaucoma, G468521196, G5489434148, G6718509927, 非標識神経伝達物質イメージセンサによる細胞活動可視化システム構築と脳機能の時空間解析, G8751478894, Origin and function of macrophages in the peripheral nervous system, G8899588464
OpenAlex ID: W4210966520