Work

Development of the mammalian main olfactory bulb

Year: 2022

Type: review

Abstract: The mammalian main olfactory bulb is a crucial processing centre for the sense of smell. The olfactory bulb forms early during development and is functional from birth. However, the olfactory system continues to mature and change throughout life as a target of constitutive adult neurogenesis. Our Review synthesises current knowledge of prenatal, postnatal and adult olfactory bulb development, focusing on the maturation, morphology, functions and interactions of its diverse constituent glutamatergic and GABAergic cell types. We highlight not only the great advances in the understanding of olfactory bulb development made in recent years, but also the gaps in our present knowledge that most urgently require addressing.

Source: Development

DOI: 10.1242/dev.200210

Authors: Candida Tufo, Subathra Poopalasundaram, Ana Dorrego-Rivas, Marc C. Ford, Anthony Graham, Matthew S. Grubb

Institution: King's College London

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: hybrid

Funders: King's College London, Biotechnology and Biological Sciences Research Council

Award: Harnessing natural cellular variability to understand how neurons maintain their axodendritic polarity