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Biomarker Development in Cardiology: Reviewing the Past to Inform the Future

Year: 2022
Type: article
Abstract: Cardiac biomarkers have become pivotal to the clinical practice of cardiology, but there remains much to discover that could benefit cardiology patients. We review the discovery of key protein biomarkers in the fields of acute coronary syndrome, heart failure, and atherosclerosis, giving an overview of the populations they were studied in and the statistics that were used to validate them. We review statistical approaches that are currently in use to assess new biomarkers and overview a framework for biomarker discovery and evaluation that could be incorporated into clinical trials to evaluate cardiovascular outcomes in the future.
Source: Cells
DOI: 10.3390/cells11030588
Authors: Katharine A. Kott, Michael Bishop, Christina H. J. Yang, Toby M. Plasto, Daniel C. Cheng, Adam I. Kaplan, Louise Cullen, David S. Celermajer, Peter J. Meikle, Stephen T. Vernon, Gemma A. Figtree
Institutions: The University of Sydney, Royal North Shore Hospital, University of Newcastle Australia, Royal Brisbane and Women's Hospital, Royal Prince Alfred Hospital, The Heart Research Institute, Baker Heart and Diabetes Institute
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $2,303
OpenAlex ID: W4211079648
FWCI: 2.328
Cites: 277
Cited by: 16
Related to: 10