Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum β-lactamases and/or AmpC β-lactamases in food and food-producing animals
Year: 2011
Type: article
Abstract: Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum β-lactamases and/or AmpC β-lactamases in food and food-producing animals1 EFSA Panel on Biological Hazards (BIOHAZ)2, 3 European Food Safety Authority (EFSA), Parma, Italy The potential contribution of food-producing animals or foods to public health risks by ESBL and/or AmpC-producing bacteria is related to specific plasmid-mediated ESBL and/or AmpC genes encoded by a number of organisms. The predominant ESBL families encountered are CTX-M, TEM, and SHV; the predominant AmpC-family is CMY. The most common genes associated with this resistance in animals are blaCTX-M-1 (the most commonly identified ESBL), and blaCTX-M-14, followed by blaTEM-52 and blaSHV-12. Among the genes encoding AmpC-type β-lactamases, blaCMY-2 is the most common.The bacterial species most commonly identified with these genes are Escherichia coli and non-typhoidal Salmonella. ESBL/AmpC transmission is mainly driven by integrons, insertion sequences, transposons and plasmids, some of which are homologous in isolates from both food-production animals and humans. Cefotaxime is used as the drug of choice for optimum detection of blaESBL
Source: EFSA Journal
Author: EFSA Panel on Biological Hazards (BIOHAZ)
Language: English
Subfield: Microbiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,400
OpenAlex ID: W4211117974