Work

Staphylococcal Biofilms

Year: 2018

Type: review

Abstract: ABSTRACT Staphylococci, with the leading species Staphylococcus aureus and Staphylococcus epidermidis , are the most frequent causes of infections on indwelling medical devices. The biofilm phenotype that those bacteria adopt during device-associated infection facilitates increased resistance to antibiotics and host immune defenses. This review presents and discusses the molecular mechanisms contributing to staphylococcal biofilm development and their in-vivo importance. Furthermore, it summarizes current strategies for the development of therapeutics against staphylococcal biofilm-associated infection.

Source: Microbiology Spectrum

DOI: 10.1128/microbiolspec.gpp3-0023-2018

Author: Michael Otto

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases

Language: English

Topic: Bacterial biofilms and quorum sensing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases