Work

Modeling Infection and Tropism of Human Parainfluenza Virus Type 3 in Ferrets

Year: 2022

Type: article

Abstract: models, providing a platform to study approaches to prevent and treat HPIV-3 infection. Although we did not detect ferret-to-ferret transmission in our studies, these studies lay the groundwork for further refinement of the ferret model to immunocompromised ferrets, allowing for studies of severe HPIV-3-associated disease. Such models for preclinical evaluation of prophylaxis and antivirals can contribute to reducing the global health burden of HPIV-3.

Source: mBio

DOI: 10.1128/mbio.03831-21

Authors: Laurine C. Rijsbergen, Katharina S. Schmitz, Lineke Begeman, Jennifer Drew-Bear, Lennert Gommers, Mart M. Lamers, Alexander L. Greninger, Bart L. Haagmans, Matteo Porotto, Rik L. de Swart, Anne Moscona, Rory D. de Vries

Institutions: Erasmus MC, Columbia University, University of Washington, Fred Hutch Cancer Center, University of Campania "Luigi Vanvitelli"

Language: English

Topic: Respiratory viral infections research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases

Awards: Engineering protease-resistant alpha-beta peptides for broad-spectrum antivirals, G5134434697

OpenAlex ID: W4212786469

FWCI: 1.625

Cites: 81

Cited by: 11

Related to: 10