Work

Anterior Mediastinal Neuroblastoma Associated with Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Morphologic, Immunohistochemical, and Genetic Case Report and Review of the Literature

Year: 2022

Type: article

Abstract: We report a mediastinal neuroblastoma in an octogenarian with paraneoplastic syndrome of inappropriate antidiuretic hormone secretion (SIADH). Neuroblastomas are very rare tumors in adults, with thoracic or mediastinal locations being especially uncommon. These neoplasms have been occasionally associated with the SIADH. Given the rarity of incidence and paucity of diagnostic and outcomes data, the significance of standard neuroblastoma prognostic characteristics is unclear, and no treatment paradigms exist for these patients. Further studies are needed to inform future clinical guidelines.

Source: International Journal of Surgical Pathology

DOI: 10.1177/10668969221080061

Authors: Gregory T. Kennedy, Christopher M. Sande, Lea F. Surrey, Feredun S. Azari, Charuhas Deshpande, Sunil Singhal

Institutions: University of Pennsylvania, Children's Hospital of Philadelphia

Language: English

Topic: Neuroblastoma Research and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Foundation for the National Institutes of Health, American Philosophical Society, Society of Thoracic Surgeons, National Cancer Institute