GBAP1 Polymorphisms (rs140081212, rs1057941 and rs2990220) Contribute to Reduced Risk of Gastric Cancer
Year: 2022
Type: article
Study design: Observational Study
Abstract: Aim: This study was designed to evaluate the contribution of GBAP1 variants to gastric cancer (GC) risk in a Chinese Han population. Methods: The genotypes of GBAP1 polymorphisms were detected using the Agena MassARRAY platform. Logistic regression analysis was used to calculate odds ratios (ORs) and 95% CIs. Results: GBAP1 rs140081212 (OR = 0.51, p = 4.50 × 10-07), rs1057941 (OR = 0.48, p = 1.19 × 10-08) and rs2990220 (OR = 0.46, p = 7.34 × 10-09) contribute to reduced GC risk, especially gastric adenocarcinoma. Interestingly, the contribution of GBAP1 variants to GC susceptibility was associated with age, sex, BMI, smoking and drinking. Conclusion: This research suggested that GBAP1 polymorphisms might provide a protective effect against GC occurrence in a Chinese Han population.
Source: Future Oncology
Authors: Xianglong Duan, Liang Shan, Shuai Shi, Boyu Xu, Xin Chen, Jinqin Di, Bopeng Chen, Xiaoqing Li, Sida Liu, Yuhe Wang, Wei Yang
Institutions: Xizang Minzu University, Shaanxi Provincial People's Hospital
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4212834812