Blood metabolites predicting mild cognitive impairment in the study of Latinos‐investigation of neurocognitive aging (HCHS/SOL)
Year: 2022
Type: article
Abstract: INTRODUCTION: Blood metabolomics-based biomarkers may be useful to predict measures of neurocognitive aging. METHODS: We tested the association between 707 blood metabolites measured in 1451 participants from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), with mild cognitive impairment (MCI) and global cognitive change assessed 7 years later. We further used Lasso penalized regression to construct a metabolomics risk score (MRS) that predicts MCI, potentially identifying a different set of metabolites than those discovered in individual-metabolite analysis. RESULTS: We identified 20 metabolites predicting prevalent MCI and/or global cognitive change. Six of them were novel and 14 were previously reported as associated with neurocognitive aging outcomes. The MCI MRS comprised 61 metabolites and improved prediction accuracy from 84% (minimally adjusted model) to 89% in the entire dataset and from 75% to 87% among apolipoprotein E ε4 carriers. DISCUSSION: Blood metabolites may serve as biomarkers identifying individuals at risk for MCI among US Hispanics/Latinos.
DOI: 10.1002/dad2.12259
Authors: Shan He, Einat Granot‐Hershkovitz, Ying Zhang, Jan Bressler, Wassim Tarraf, Bing Yu, Tianyi Huang, Donglin Zeng, Sylvia Wassertheil‐Smoller, Melissa Lamar, Martha Daviglus, Maria J. Marquine, Jianwen Cai, Thomas Mosley, Robert Kaplan, Eric Boerwinkle, Myriam Fornage, Charles DeCarli, Bruce Kristal, Hector M. Gonzalez, Tamar Sofer
Institutions: Brigham and Women's Hospital, Harvard University, The University of Texas Health Science Center at Houston, Wayne State University, University of North Carolina at Chapel Hill, Albert Einstein College of Medicine, Rush University Medical Center, University of Illinois Chicago, University of California San Diego, University of Mississippi Medical Center, Fred Hutch Cancer Center, Baylor College of Medicine, Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of California, Davis, Cornell University, Burke Medical Research Institute, Weill Cornell Medicine
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,200
Funders: U.S. Department of Health and Human Services, Office of Dietary Supplements, U.S. Department of State, American Academy of Arts and Sciences, Massachusetts General Hospital, University of Miami, Northwestern University, San Diego State University, National Institutes of Health, University of Illinois at Urbana-Champaign, Gillings School of Public Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Dental and Craniofacial Research, National Institute on Minority Health and Health Disparities
Awards: G1081972346, G1114307781, G1121130830, G1140476625, G1201667161, G122677224, G1262629770, G1312369436, G1327559120, G1349668216, G1455175283, Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA), G1522370804, MRI Measures of Cerebrovascular Injury and AD Atrophy in a Study of Latinos, G1788514665, G1818487580, G1823732541, G1845395357, G1866572497, G1984718218, G2128161193, G2262505034, G2462410987, G2466919156, G2494211023, G2644289446, G2651066328, G2655143993, G2701926366, G2775889581, G2780798618, G2866617920, G2874865971, G3051506083, G3332710595, G3614733703, G3667269547, G3722034730, GWA for Gene-Environment Interaction Effects Influencing CHD, G3744596180, G3801540856, G3808803955, G3973572274, G4068323944, G4143790175, G4216906458, G4230684217, G432753757, G4421869008, G4497211205, G4597579782, G4739409156, G4747441672, G4790942633, G5015503974, G508454511, G5102588038, G528357465, G5352314984, G5372897717, G5430416737, G543802643, G5752304122, G5770678025, G5785169696, G5928944960, G5935820280, G596642789, G5988662542, G6060132884, G6088185517, G6149955053, G6170501256, G6202424770, G627395113, G6405494218, Neurocognitive aging, MCI and Alzheimer's disease DNA methylation among diverse Latinos, G665587953, G6676983573, G6739173425, G6837735701, G6914194341, G7002085061, G7132511053, G7155745631, G7416109258, G7535686976, G7667010295, G8022343337, Exploring Sleep in Neurocognitive Aging and Alzheimer's Research (eSANAR), G820454163, G8328619368, G8556167647, G8738262636, HISPANIC COMMUNITY HEALTH STUDY-268065233, G8932431361, G8987601928, G9000101987, G9000199330, UCSD Shiley-Marcos Alzheimer's Disease Research Center P30, San Diego Alzheimer's Disease Resource Center for Minority Aging Research (San Diego AD-RCMAR), G916230891, G937084196, G940445018
OpenAlex ID: W4212914583