Towards the synthesis of ssDNA-based SuFEx probes targeting APOBEC3B DNA cytosine deaminase
Year: 2020
Type: other
Abstract: One of the major challenges in the construction of nanomaterials is the difficulty of synthesizing materials with well defined, homogeneous structures. However nature shows the innate ability of yielding homogeneous structures that are arranged at the molecular level through construction of diverse bio-nanomaterials through the non-covalent self-assembly of proteins. Inspired by the bio-specificity and driven self-assembly of proteins/peptides, the research presented investigates the use of peptides to construct molecular building blocks (MBBs) that provide step-by-step control of the bottom up self-assembly of nanostructures. The strategy looks at constructing MBBs by exploiting coiled coil forming peptide sequences with two connected faces that are bio-specific and only associate with their designed partners allowing association and assembly when complementary building blocks are added. The results presented here are for the synthetic peptide synthesis of the coiled coil peptides containing non-natural amino acids that allow cross-linking between peptides to produce MBBs and preliminary results for their construction and assembly.
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W4212929818