TAZ is important for maintenance of the integrity of podocytes
Year: 2022
Type: article
Abstract: Podocytes play an important role in maintaining the integrity of the structure and function of the kidney. We observed that mice with selective deletion of transcriptional coactivator with PDZ-binding motif (TAZ) in podocytes developed proteinuria. TAZ is constitutively active and critical for expression of synaptopodin, zonula occludens-1, and zonula occludens-2 in podocytes. The findings of this study implicate TAZ as an important mediator of podocyte structural integrity and provide further insights into the role of Hippo-Yes-associated protein/TAZ in podocyte biology.
Authors: Jianchun Chen, Xiaoyong Wang, Qian He, Raymond C. Harris
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1187429744, Mechanisms of EGFR Activation and Signaling in Kidney Disease, G1433450062, Vanderbilt O'Brien Mouse Kidney Physiology and Disease Center, G2343639586, G336524319, Vanderbilt O'Brien Kidney Center, G461871522, G6313819268, G6792221346, The role of the innate immune cell cyclooxygenase/prostaglandin system in blood pressureregulation
OpenAlex ID: W4212932253