Hormone-Dependent Regulation of Renin and Effects on Prorenin Receptor Signaling in the Collecting Duct
Year: 2022
Type: article
Abstract: : The production of renin by the principal cells of the collecting duct has widened our understanding of the regulation of intrarenal angiotensin II (Ang II) generation and blood pressure. In the collecting duct, Ang II increases synthesis and secretion of renin by mechanisms involving the activation of Ang II type 1 receptors (AT1R) via stimulation of the PKCα, Ca2+ and cAMP/PKA/CREB pathways. Additionally, paracrine mediators, including vasopressin (AVP), prostaglandins, bradykinin (BK) and atrial natriuretic peptide (ANP) regulate renin in principal cells. During Ang II-dependent hypertension, despite plasma renin activity suppression, the renin and prorenin receptor (PRR) are upregulated in the collecting duct and promote de novo formation of intratubular Ang II. Furthermore, activation of PRR by its natural agonists, prorenin and renin, may contribute to the stimulation of profibrotic factors, independent of Ang II. Thus, the interactions of RAS components with paracrine hormones within the collecting duct enables tubular compartmentalization of the RAS to orchestrate complex mechanisms that increase intrarenal Ang II, Na+ reabsorption and blood pressure.
Source: Current Hypertension Reviews
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, Fondo Nacional de Ciencia y Tecnología, National Institutes of Health, Ciência sem Fronteiras, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences, Fondo Nacional de Desarrollo Científico y Tecnológico
OpenAlex ID: W4213040369