Year: 2012
Type: article
Abstract: We are grateful for the opportunity to comment on the letter by Polesel et al. on their study on coffee and prostate cancer risk. Indeed, given the novel findings of our initial report, we recognize the important role of the research community in validating these results in additional study populations. The authors report no evidence for an inverse association between coffee consumption and the risk of total prostate cancer or Gleason grade 7–10 disease. It is noteworthy that the odds ratios and confidence intervals reported in the correspondence are, in fact, compatible with our own results. We found only a modest inverse association for total prostate cancer risk, and for grade 8–10 cancers, we found an inverse association only in the highest category of intake with no dose-response. Moreover, although rereviewed Gleason grade is an important predictor of prostate cancer outcomes, there are inherent challenges in deriving grade information from original pathology reports. There are well-documented shifts in grading over time and across institutions ( 1 , 2 ), which may influence epidemiological studies that use historical Gleason data, including our own.
DOI: 10.1093/jnci/djs380
Authors: K. M. Wilson, E. Giovannucci, L. A. Mucci
Institutions: Brigham and Women's Hospital, Harvard University
Language: English
Topic: Coffee research and impacts
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4213079327