Insulin blood-brain barrier transport and interactions are greater following exercise in mice
Year: 2022
Type: article
Abstract: Central nervous system (CNS) insulin and exercise are beneficial for cognition. CNS insulin resistance is present in Alzheimer's disease. CNS insulin levels are regulated by transport across the blood-brain barrier (BBB). We show that exercise can enhance insulin BBB transport and binding of insulin to the brain's vasculature in mice. There were no changes in serum factors known to alter insulin BBB pharmacokinetics. We conclude exercise could impact cognition through regulation of insulin BBB transport.
Source: Journal of Applied Physiology
Authors: Caitlin Brown, Sarah Pemberton, Alice Babin, Noor Abdulhameed, Cassidy Noonan, Mary Beth Brown, William A. Banks, Elizabeth M. Rhea
Institutions: VA Puget Sound Health Care System, University of Washington
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4213149191