Work

Convergent synthesis of (+)-carambolaflavone A, an antidiabetic agent using a bismuth triflate-catalyzed C -aryl glycosylation

Year: 2022

Type: article

Abstract: -glycosyl flavonoids. The glycosylation partners were synthesized from commercially available (±)-naringenin and D-(+)-galactose, respectively. An oxidative bromination and elimination reaction sequence was utilized to construct the flavone. The natural product is obtained in 13 steps (longest linear sequence) from D-(+)-galactose.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/d2ob00038e

Authors: Arun K. Ghosh, William L. Robinson, John Gulliver, Hannah M. Simpson

Institution: Purdue University West Lafayette

Language: English

Topic: Synthesis of Organic Compounds

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences

Awards: Mechanisms of the spliceosome protein SF3B1 and inhibitors, Cancer Center Support Grant