Design of a Novel Fab‐Like Antibody Fragment with Enhanced Stability and Affinity for Clinical use (Small Methods 2/2022)
Year: 2022
Type: article
Abstract: Front Cover In article number 2100966, Hong, Wu, Ying and coworkers provide a novel approach to antibody design in which the CH1 and CL domains of Fab were replaced by the engineered IgG1 CH3 domains. This novel Fab-like antibody fragment, designated as FabCH3, has higher stability and antigen-binding affinity than the parental Fab. The superior efficacy of FabCH3 over Fab has also been demonstrated in vivo.
Source: Small Methods
Institutions: Shanghai Medical College of Fudan University, Fudan University, Affiliated Hospital of Guizhou Medical University, Eye & ENT Hospital of Fudan University, Zhongshan Hospital, MRC Centre for Reproductive Health, The Queen's Medical Research Institute, University of Edinburgh, University of Pittsburgh
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4213177684