08 - Characterizing Chemotherapy-induced Peripheral Neuropathy Assessment and Management Documentation Patterns in Ambulatory Oncology Clinics
Year: 2019
Type: other
Abstract: INTRODUCTION: Over half of patients receiving taxane, platinum, or bortezomib chemotherapy experience CIPNu2014a dose-limiting toxicity with numbness, pain, and muscle problems in the extremities. This randomized pilot study explored whether exercise improves CIPN symptoms and physical function.METHODS: Nineteen patients to receive taxane, platinum, or bortezomib were randomized to exercise (home-based, low-moderate-intensity, walking+resistance training; EXCAPu00a9u00ae) or nutrition education (control) for 12 weeks upon first infusion. At 0, 6, and 12 weeks, we assessed CIPN symptoms via CIPN-20 sensory scale (9-36, higher is worse). We assessed physical function via leg strength (Biodex) and six-minute walk. Linear regression modeled each outcome, tested for effects of exercise, and controlled for baseline and age because controls were older. Because this is a pilot study, we present effect sizes, not p-values.RESULTS: The 19 patients were 65u00b111 years, 52% women, with cancer: 42% breast, 32% gastrointestinal, 16% myeloma, 10% genitourinary. Exercise mitigated CIPN symptoms. At 6 weeks, exercisers increased 11.0 to 12.5 whereas controls increased 11.0 to 15.5 (+1.5 vs. +4.5; ES=0.81). At 12 weeks, exercisers increased 11.0 to 14.8 whereas controls increased 11.0 to 16.2 (+3.8 vs. +5.2, ES=0.46). Exercisers improved leg strength vs. controls (ES=0.35 and 0.28 at 6 and 12 weeks) and six-minute walk distance at 6 weeks vs. controls (1,721 vs. 1,631 ft; ES=0.22) but walked slightly less than controls at 12 weeks (1,679 vs. 1,705; ES=-0.16).CONCLUSION: Exercise during neurotoxic chemotherapy mitigated CIPN symptoms and improved physical function. Future work should test for replication with a larger sample. NCT03021174.
Authors: Robert Knoerl, Donna L Berry
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4213221301