Year: 2017
Type: article
Abstract: Traditionally, viral vaccines have been based on inactivated or live attenuated viruses. While in general, they are highly effective, in some cases they fail to provide adequate immunogenicity, safety or can even cause adverse events. In the case of live attenuated vaccines, achieving a stable optimally attenuated virus is often difficult and there is the potential for reversion. Transmission to the immunocompromised individuals is an additional concern. Inactivated vaccines run the risk of inducing enhanced disease. Single proteins, including single protein nano-particle vaccine attempts have not been successful to date for human use. Various other ways of making vaccines have also been attempted by engineering the virus.
DOI: 10.17140/vroj-2-e003
Author: Pramila Walpita
Institutions: University of Hawaiʻi at Mānoa, University of Hawaii System
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4213347136