Year: 2022
Type: article
Abstract: Blood clotting disorders such as pulmonary embolism are associated with high morbidity and mortality. A large portion of thrombotic events occur postoperative and after hospital discharge. Therefore, easily applicable, noninvasive, and long-term monitoring of thrombosis occurrence is critical for urgent clinical intervention. Here, the use is proposed of ionic liquids as a skin transport facilitator to deliver thrombin-sensitive nanosensors that enable prolonged monitoring of pulmonary embolism. Co-formulation of nanosensors with choline and geranic acid (CAGE) ionic liquids demonstrates significant transdermal diffusion into the dermis of the skin and provides sustained release into the blood throughout 72 h. Upon reaching the systemic circulation, the nanosensors release reporter molecules into the urine by responding to activation of the clotting cascade and retain a diagnostic power for 24 h in an acute pulmonary embolism mouse model. These results demonstrate a proof-of-concept disease monitoring system that can be topically applied by patients and potentially reduce mortality and high cost of hospitalization.
Source: Advanced Healthcare Materials
Institutions: Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Harvard University, University of Mississippi, Koch Institute for Integrative Cancer Research At MIT, Wyss Institute for Biologically Inspired Engineering, Broad Institute, Brigham and Women's Hospital
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,300
Funders: National Science Foundation, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Moderna, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, National Institutes of Health, Ludwig Center at Harvard, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Environmental Health Sciences
Awards: G1148400999, Molecular Biophysics Training Grant, G2360436881, G3455539091, G3905928662, MIT Center for Environmental Health Sciences, G4170621125, G4774430914, G5108852245, G524113085, In vivo investigation and modulation of biomolecular corona for improved nanotherapeutics, G9000300833, Cancer Center Support (Core) Grant
OpenAlex ID: W4213390764