Work

Common and differential features of liver and pancreatic cancers: molecular mechanism approach.

Year: 2021

Type: article

Abstract: AIM: The aim of this study was to introduce biomarkers commonly involved in pancreatic cancer metastasis to the liver. BACKGROUND: The liver is affected by metastatic disease in pancreatic cancer. METHODS: Two cancer biomarkers were distinguished through a STRING database protein query. The dysregulated proteins of the two cancers were included in 2 networks drawn by Cytoscape software v 3.2.7. 20 top nodes and achieved by the Network analyzer application of Cytoscape based on degree value. The common hub nodes were determined, and action maps were analyzed. RESULTS: Among 20 hubs of each studied cancer, 18 common hub nodes (90% of hubs) were identified and screened by action maps. Four proteins, AKT1, CDKN2A, ERBB2, and IL6, were identified as common central proteins related to the two studied diseases. CONCLUSION: AKT1, CDKN2A, ERBB2, and IL6 are common protein core of liver and pancreatic cancers, while STAT3, CASP3, NOTCH1, and CTNNB1 are possible differential proteins to discriminate these cancers.

Source: Gastroenterology and hepatology from bed to bench.

Authors: Kourosh Saki, Vahid Mansouri, Nastaran Asri, Mohammad Fathi, Zahra Razzaghi

Institutions: Shahid Beheshti University, Shahid Beheshti University of Medical Sciences, Research Institute for Gastroenterology and Liver Diseases

Language: English

Topic: Pancreatic and Hepatic Oncology Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Shahid Beheshti University of Medical Sciences

OpenAlex ID: W4213393691

FWCI:

Cites: 58

Cited by: 1

Related to: 10