Influence of locomotor muscle group III/IV afferents on cardiovascular and ventilatory responses in human heart failure during submaximal exercise
Year: 2022
Type: article
Abstract: Patients with HFrEF exhibit severe exercise intolerance. One of the primary peripheral mechanisms contributing to exercise intolerance in patients with HFrEF is locomotor muscle group III/IV afferent feedback. However, it is unknown whether these afferents impact the central and peripheral responses during submaximal cycling exercise. Herein, we demonstrate that inhibition of locomotor muscle group III/IV afferent feedback elicited increases in stroke volume during submaximal exercise in HFrEF, but not in healthy controls.
Source: Journal of Applied Physiology
Institutions: Mayo Clinic, University of Minnesota, Cleveland Clinic
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Mayo Clinic Building Interdisciplinary Research Careers in Women’s Health, HL-Inorganic Nitrite to Enhance Benefits from Exercise Training in Heart Failure with preserved Ejection Fraction, G1758577523, G2314746108, Peripheral Mechanisms of Cardiopulmonary Control during Exercise, G2944892832, Autonomic regulation of blood pressure in premature and early menopausal women, G4915886023, G5398318722, Variant Hemoglobin and Cardiorespiratory Regulation in Humans, Musculoskeletal Research Training Program, Cardiovasology
OpenAlex ID: W4213451225