Associations Between Brainstem Volume and Alzheimer’s Disease Pathology in Middle-Aged Individuals of the Framingham Heart Study
Year: 2022
Type: article
Abstract: The brainstem is among the first regions to accumulate Alzheimer's disease (AD)-related hyperphosphorylated tau pathology during aging. We aimed to examine associations between brainstem volume and neocortical amyloid-β or tau pathology in 271 middle-aged clinically normal individuals of the Framingham Heart Study who underwent MRI and PET imaging. Lower volume of the medulla, pons, or midbrain was associated with greater neocortical amyloid burden. No associations were detected between brainstem volumes and tau deposition. Our results support the hypothesis that lower brainstem volumes are associated with initial AD-related processes and may signal preclinical AD pathology.
Source: Journal of Alzheimer s Disease
DOI: 10.3233/jad-215372
Authors: Heidi I.L. Jacobs, Adrienne O’Donnell, Claudia L. Satizabal, Cristina Lois, Daniel Kojis, Bernard J. Hanseeuw, Emma Thibault, Justin S. Sanchez, Rachel F. Buckley, Qiong Yang, Charles DeCarli, Ron Killiany, Muralidharan Sargurupremraj, Reisa A. Sperling, Keith A. Johnson, Alexa S. Beiser, Sudha Seshadri
Institutions: Harvard University, Maastricht University, Gordon Center for Medical Imaging, Massachusetts General Hospital, Boston University, Framingham Heart Study, The University of Texas at San Antonio Health Science Center, Cliniques Universitaires Saint-Luc, UCLouvain, KU Leuven, The University of Melbourne, University of California, Davis, Brigham and Women's Hospital
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Elevated locus coeruleus metabolism as mechanism driving Alzheimer's disease pathology, G278200998, G3405256882, ADSP Follow-up in Multi-Ethnic Cohorts via Endophenotypes, Omics & Model Systems, G4976486911, Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham Cohorts, Preclinical AD: Correlates of Amyloid, Tau PET and fcMRI in Framingham Gen 3 Young Adults, Sex differences in the progression of Alzheimer's disease: is menopause the key?, Tracking the origin of tau pathology, Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC), Precursors of Stroke Incidence and Prognosis, The wandering nerve: gateway to boost Alzheimer's disease related cognitive performance, South Texas Alzheimer's Disease Center
OpenAlex ID: W4214537630