The Current and Evolving Therapeutic Paradigm in the Management of Metastatic Renal Cell Carcinoma
Year: 2021
Type: article
Abstract: There has been tremendous progress in the treatment landscape of advanced or metastatic RCC with novel and efficacious targeted therapies, immunotherapies and combinatorial regimens, leading to an expansion of therapeutic armamentarium over the last two decades. New advances have offered considerable improvement in prognosis, treatment-related toxicities, quality of life, and survival for patients with mRCC. Despite such advantages, there is unmet need for developing novel biomarkers predictive of treatment response, optimize treatment selection, and also improving strategies to overcome therapeutic resistance in heterogenous RCC tumors. Herein, we outline currently available first- and subsequent-lines treatment strategies, unprecedented changes, and also discuss challenges in treatment landscape of RCC.
Source: Kidney Cancer Journal
DOI: 10.52733/kcj19n3-r1
Authors: Thomas Hutson, Robert Figlin
Institution: Cedars-Sinai Medical Center
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4214553516