Year: 2022
Type: editorial
Abstract: Macroautophagy/autophagy plays crucial roles in aging and the pathogenesis of age-related diseases. Studies in various animal models demonstrate the conserved requirement for autophagy-related genes in multiple anti-aging interventions. A recent study from the Shirasu-Hiza lab showed that a newly designed intermittent time-restricted feeding (iTRF) dietary regimen can robustly extend fly healthspan and lifespan through circadian rhythm-dependent activation of autophagy. The night-specific induction of autophagy is both necessary and sufficient for iTRF-mediated health benefits. The study provides the intriguing possibility that novel behavioral or pharmaceutical interventions that promote night-specific autophagy can be used to promote healthy aging.
Source: Autophagy
Authors: Zhangyuan Yin, Daniel J. Klionsky
Institution: University of Michigan
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4214695476