Work

Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations

Year: 2022

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.1c01774

Authors: Chuan Zhou, Zisheng Fan, Zehui Zhou, Yupeng Li, Rongrong Cui, Chaoyi Liu, Guizhen Zhou, Xingxing Diao, Hualiang Jiang, Mingyue Zheng, Sulin Zhang, Tianfeng Xu

Institutions: Chinese Academy of Sciences, Shanghai Institute of Materia Medica, Nanjing University of Chinese Medicine, State Key Laboratory of Drug Research, University of Chinese Academy of Sciences, University of Minnesota, Masonic Cancer Center

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: Natural Science Foundation of Shanghai, National Natural Science Foundation of China, China Postdoctoral Science Foundation, Science and Technology Commission of Shanghai Municipality

Awards: G2542711507, G3148159234, 靶向诱导SOS1蛋白质降解的小分子的设计、合成及抗肿瘤活性研究

OpenAlex ID: W4214695568

FWCI: 6.397

Cites: 30

Cited by: 93

Related to: 10