Optoplasmonic Whispering Gallery Mode Sensors for Single Molecule Characterization: A Practical Guide
Year: 2022
Type: book-chapter
Abstract: Optoplasmonic sensors are a new class of single-molecule sensors that leverage the exceptional quality factor of dielectric micro cavities and the strong localization of electromagnetic fields by metal nanoparticles. These sensors have even enabled the detection of the smallest entities in solution, that is, single atomic ions. This chapter describes the working principle of these sensors with a focus on the experimental aspects of the sensor. An overview of various dielectric micro cavities and their fabrication techniques is provided. The synthesis and fabrication of metal nanoparticles and the techniques for combining them with micro cavities are also discussed. Various aspects of the sensor such as the sensitivity, limits of detection, time resolution, methods for functionalization, and robustness are discussed. Finally, solutions and approaches to overcome many of the limitations are presented and an outlook on the future applications of these sensors is presented.
Institution: University of Exeter
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W4214732721