Fertility preservation for female patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group
Year: 2021
Type: article
Abstract: Female patients with childhood, adolescent, and young adult cancer are at increased risk for fertility impairment when treatment adversely affects the function of reproductive organs. Patients and their families desire biological children but substantial variations in clinical practice guidelines reduce consistent and timely implementation of effective interventions for fertility preservation across institutions. As part of the PanCareLIFE Consortium, and in collaboration with the International Late Effects of Childhood Cancer Guideline Harmonization Group, we reviewed the current literature and developed a clinical practice guideline for fertility preservation in female patients who were diagnosed with childhood, adolescent, and young adult cancer at age 25 years or younger, including guidance on risk assessment and available methods for fertility preservation. The Grading of Recommendations Assessment, Development and Evaluation methodology was used to grade the available evidence and to form the recommendations. This clinical practice guideline leverages existing evidence and international expertise to develop transparent recommendations that are easy to use to facilitate the care of female patients with childhood, adolescent, and young adult cancer who are at high risk for fertility impairment. A complete review of the existing evidence, including a quality assessment, transparent reporting of the guideline panel's decisions, and achievement of global interdisciplinary consensus, is an important result of this intensive collaboration.
Source: The Lancet Oncology
Authors: Renée L Mulder, Anna Font-Gonzalez, Melissa M Hudson, Hanneke M van Santen, Erik A H Loeffen, Karen C Burns, Gwendolyn P Quinn, Eline van Dulmen-den Broeder, Julianne Byrne, Riccardo Haupt, W Hamish Wallace, Marry M van den Heuvel-Eibrink, Antoinette Anazodo, Richard A Anderson, Anke Barnbrock, Joern D Beck, Annelies M E Bos, Isabelle Demeestere, Christian Denzer, Natascia Di Iorgi, Holly R Hoefgen, Rejin Kebudi, Cornelis Lambalk, Thorsten Langer, Lillian R Meacham, Kenny Rodriguez-Wallberg, Catharyn Stern, Eveline Stutz-Grunder, Wendy van Dorp, Margreet Veening, Saskia Veldkamp, Eline van der Meulen, Louis S Constine, Lisa B Kenney, Marianne D van de Wetering, Leontien C M Kremer, Jennifer Levine, Wim J E Tissing, Claire Berger, Tamara Diesch, Uta Dirksen, Jill Ginsberg, Aleksander Giwercman, Desiree Grabow, Clarisa Gracia, Sarah E Hunter, Julia Inthorn, Peter Kaatsch, Joanne F Kelvin, James L Klosky, Joop S E Laven, Barbara A Lockart, Sebastian JCMM Neggers, Norbert W Paul, Michelle Peate, Bob Phillips, Damon R Reed, Eva Maria E Tinner, Marleen van den Berg, Chris Verhaak
Institutions: Princess Máxima Center, Emma Kinderziekenhuis, Amsterdam University Medical Centers, University of Amsterdam, St. Jude Children's Research Hospital, University Medical Center Utrecht, Wilhelmina Children's Hospital, University Medical Center Groningen, University of Groningen, Beatrix Kinderziekenhuis, Cincinnati Children's Hospital Medical Center, University of Cincinnati, New York University, Vrije Universiteit Amsterdam, Boyne Research Institute, Istituto Giannina Gaslini, Royal Hospital for Sick Children, Erasmus MC, Erasmus MC - Sophia Children’s Hospital, UNSW Sydney, Prince of Wales Hospital, Sydney Children's Hospital, MRC Centre for Reproductive Health, University of Edinburgh, Goethe University Frankfurt, University Hospital Frankfurt, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, University of Lübeck, Université Libre de Bruxelles, Erasmus Hospital, Universität Ulm, University Hospital Ulm, University of Genoa, Washington University in St. Louis, Istanbul University-Cerrahpaşa, Istanbul University, University Hospital Schleswig-Holstein, Emory University, Children's Healthcare of Atlanta, Karolinska University Hospital, Karolinska Institutet, Royal Women's Hospital, University of Zurich, University Children's Hospital Zurich, University of Rochester Medicine, University of Rochester, Boston Children's Hospital, Harvard University, Dana-Farber Cancer Institute, Cornell University, Weill Cornell Medicine
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,000
OpenAlex ID: W4214825610