Work

Synthesis of phosphatidic acids via cobalt(salen) catalyzed epoxide ring-opening with dibenzyl phosphate

Year: 2022

Type: article

Abstract: With a CoIII(salen)OTs catalyst, dibenzyl phosphate ring-opens a variety of terminal epoxides with excellent regio-selectively and yields up to 85%. The reaction is used in a highly efficient synthesis of enantiopure mixed-diacyl phosphatidic acids, including a photoswitchable phosphatidic acid mimic.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/d2ob00168c

Authors: Ruben L. H. Andringa, Marijn Jonker, Adriaan J. Minnaard

Institution: University of Groningen

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funders: Rijksuniversiteit Groningen, Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Award: G5194781092