Ultra-high sensitivity cardiac troponin-I concentration and left ventricular structure and function in women with ischemia and no obstructive coronary artery disease
Year: 2022
Type: article
Abstract: Women are disproportionally impacted by ischemia and no obstructive coronary artery disease (INOCA), and such women are at increased risk of developing heart failure with preserved ejection fraction (HFpEF), however the mechanisms linking these conditions remain poorly understood. The aim of this study was to determine whether ultra-high sensitivity cardiac troponin I (u-hscTnI), an indicator of cardiomyocyte injury, is associated with abnormalities in myocardial perfusion and left ventricular (LV) structure and function in women with INOCA. 327 women with INOCA enrolled in the Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction (WISE-CVD) study underwent vasodilator stress cardiac magnetic resonance imaging (CMRI) and u-hscTnI measurements (Simoa HD-1 Analyzer, Quanterix Corporation). Multivariable linear regression was used to evaluate associations between u-hscTnI concentrations and myocardial perfusion (MPRI), LV mass index and feature-tracking derived strain measures of LV function. u-hscTnI concentrations were quantifiable in 100% of the cohort and ranged from 0.004 to 79.6 pg/mL. In adjusted models, u-hscTnI was associated with LV mass index (+2.03; 95% CI 1.17, 2.89; p < 0.01) and early diastolic radial strain rate (SR) (+0.13; 95% CI 0.01, 0.25; p = 0.03), early diastolic circumferential SR (−0.04; 95% CI −0.08, 0.002; p = 0.06) and early diastolic longitudinal SR (−0.03; 95% CI −0.07, 0.002; p = 0.06). u-hscTnI was not associated with MPRI (p = 0.39) in adjusted models. Together, these findings support cardiomyocyte injury as a putative pathway towards adverse LV remodeling and dysfunction; however, further research is needed to define the specific mechanism(s) driving myocellular injury in INOCA.
Authors: Odayme Quesada, Omeed Elboudwarej, Michael D. Nelson, Ahmed Al-Badri, Mitra Mastali, Janet Wei, Bijan Zarrabi, Nissi Suppogu, Haider Aldiwani, Puja Mehta, Chrisandra Shufelt, Galen Cook-Wiens, Daniel S. Berman, Louise E.J. Thomson, Eileen Handberg, Carl J. Pepine, Jennifer E. Van Eyk, C. Noel Bairey Merz
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,650
Funders: U.S. Department of Health and Human Services, Gustavus and Louise Pfeiffer Research Foundation, Deutsches Krebsforschungszentrum, Society for Women’s Health Research, Ladies Hospital Aid Society, Cedars-Sinai Medical Center, Adelson Family Foundation, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Center for Research Resources, National Center for Advancing Translational Sciences, Congressionally Directed Medical Research Programs
Awards: G1134269671, G114384596, G1313999278, G1369121676, G1438650436, G1515363210, G1629590552, G1653274783, G1710551794, G1764559527, G1989727782, Behavioral Medicine and Cardiovascular Research Training, G2082575005, G2479835689, G2540502964, G2620772713, G2689173254, G276921238, G2907749685, G2933049717, G310026855, G327285978, UCLA Clinical and Translational Science Institute, G3477403096, G3637194313, Hypertensive Disorders of Pregnancy: Pathways to Future Cardiovascular Disease, G430456586, G453528718, G4635505503, G5103568212, G5394483415, G545546532, G59467377, Magnetic Resonance Imaging for Global Atherosclerosis Risk Assessment, G7078459433, G7086251139, G7522279745, G754274488, G7636702871, G7781681247, G7884066925, G7932595472, G8235554331, G842763687, G8464885619, G8638816353, G8664061136, Cardiac Autonomic Function in Women, G8844551410, G9000009309, G9000019314, G9000048965, G9000059892, G9000112759, G9000118442, G9000119693, G9000129430, G9000158322, G9000166703, G9000218046, G9000276481, G9000299718, G950221744
OpenAlex ID: W4214901905