Clinical magnetic hyperthermia requires integrated magnetic particle imaging
Year: 2022
Type: review
Abstract: Magnetic nanomaterials that respond to clinical magnetic devices have significant potential as cancer nanotheranostics. The complexities of their physics, however, introduce challenges for these applications. Hyperthermia is a heat-based cancer therapy that improves treatment outcomes and patient survival when controlled energy delivery is combined with accurate thermometry. To date, few technologies have achieved the needed evolution for the demands of the clinic. Magnetic fluid hyperthermia (MFH) offers this potential, but to be successful it requires particle-imaging technology that provides real-time thermometry. Presently, the only technology having the potential to meet these requirements is magnetic particle imaging (MPI), for which a proof-of-principle demonstration with MFH has been achieved. Successful clinical translation and adoption of integrated MPI/MFH technology will depend on successful resolution of the technological challenges discussed. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Diagnostic Tools > In Vivo Nanodiagnostics and Imaging.
DOI: 10.1002/wnan.1779
Authors: Sean Healy, Andris F. Bakuzis, Patrick W. Goodwill, Anilchandra Attaluri, Jeff W. M. Bulte, Robert Ivkov
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,300
Awards: Translational Application of Magnetic Hyperthermia Therapy with Adjuvant Therapies for Glioblastoma, Non-Invasive Tracking of Genome-Corrected iPS cells in ALS, G638922221, Color MPI as a novel method for in vivo assessment of magnetic nanoparticle dynamics and binding, Enhancing Liver Cancer Treatment With Image-Guided Magnetic Hyperthermia, Magnetic Particle Imaging Scanner, G8294048942, Precision magnetic hyperthermia by integrating magnetic particle imaging
OpenAlex ID: W4214949720