Year: 2022
Type: article
Abstract: Aging affects almost all aspects of an organism-its morphology, its physiology, its behavior. Isolating which biological mechanisms are regulating these changes, however, has proven difficult, potentially due to our inability to characterize the full repertoire of an animal's behavior across the lifespan. Using data from fruit flies (D. melanogaster) we measure the full repertoire of behaviors as a function of age. We observe a sexually dimorphic pattern of changes in the behavioral repertoire during aging. Although the stereotypy of the behaviors and the complexity of the repertoire overall remains relatively unchanged, we find evidence that the observed alterations in behavior can be explained by changing the fly's overall energy budget, suggesting potential connections between metabolism, aging, and behavior.
Source: PLoS Computational Biology
Institutions: Emory University, Princeton University
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,655
Awards: G1997189880, G2046772247, G2490179851, Collaborative Research: Formation of a High Flux Student Research Network (HF-SRN) as a Laboratory for Enhancing Interaction in the PoLS SRN, PFC: Center for the Physics of Biological Function, G3817106646, G4816072901, G5520316217, G5812093873, G5864551813, A new paradigm for quantifying animal behavior in a model genetic system, CRCNS:Predictability as a New Paradigm for Rodent Social Neurobiology
OpenAlex ID: W4220659770