Year: 2022
Type: article
Abstract: etabolic syndrome (MetS) refers to a cluster of risk factors that include central obesity, high LDL (low-density lipoprotein) and low HDL (highdensity lipoprotein) cholesterol, hyperglycemia or insulin resistance, and hypertension.MetS serves as the major risk factor for cardio-metabolic diseases including atherosclerosis, type 2 diabetes, and nonalcoholic fatty liver disease. 1 Although the relationship between MetS and atherosclerosis is well established, the cellular and molecular basis that causes these diverse traits to cluster in a single disease entity is not known, although obesity-induced insulin resistance is hypothesized as a unifying factor.Diets high in sugar and fat can contribute to obesity, insulin resistance, and type 2 diabetes, but it is less clear how this diet may promote hypertension and its potentially serious sequelae of heart failure, stroke, and myocardial infarction.
Source: Circulation Research
Authors: Arya Mani, John Hwa, Kathleen A. Martin
Institution: Yale University
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G2536109765, Coordinated regulation of vascular smooth muscle phenotype by p300, CBP, and TET2, Novel insights into intimal hyperplasia in cardiac allograft vasculopathy, The Identification and characterization of genetic variants underlying cardiovascular diseases, G534342068, Platelets in vascular injury repair, G669184102
OpenAlex ID: W4220667754