Work

Histone Deacetylases 1 and 2 in Memory Function

Year: 2022

Type: review

Abstract: Histone deacetylases (HDACs) have been implicated in learning and memory, and their dysregulation has been linked to cognitive impairment in brain aging and neurodegenerative diseases. In this review, we focus on HDAC1 and HDAC2, highlighting recent progress on their roles in regulating brain function through distinct mechanisms, including gene repression and DNA repair pathways. Moreover, we discuss evidence demonstrating how HDAC1 and HDAC2 could be modulated and their potential as targets to combat memory deficits.

Source: ACS Chemical Neuroscience

DOI: 10.1021/acschemneuro.1c00775

Authors: Ping-Chieh Pao, Li-Huei Tsai

Institution: Massachusetts Institute of Technology

Language: English

Topic: Histone Deacetylase Inhibitors Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Glenn Foundation for Medical Research, National Institute of Neurological Disorders and Stroke