Work

Goal discrimination in hippocampal nonplace cells when place information is ambiguous

Year: 2022

Type: article

Abstract: SignificanceGoal-directed spatial navigation has been found to rely on hippocampal neurons that are spatially modulated. We show that "nonplace" cells without significant spatial modulation play a role in discriminating goals when environmental cues for goals are ambiguous. This nonplace cell activity is performance-dependent and is modulated by gamma oscillations. Finally, nonplace cell goal discrimination coding fails in a mouse model of Alzheimer's disease (AD). Together, these results show that nonplace cell firing can signal unique task-relevant information when spatial information is ambiguous; these signals depend on performance and are absent in a mouse model of AD.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.2107337119

Authors: Lu Zhang, Stephanie M. Prince, Abigail L. Paulson, Annabelle C. Singer

Institutions: Georgia Institute of Technology, Emory University

Language: English

Topic: Memory and Neural Mechanisms

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: hybrid

Funders: National Science Foundation, David and Lucile Packard Foundation, National Institute on Aging, National Institute of Neurological Disorders and Stroke

Awards: Effects of non-invasive gamma stimulation on hippocampal neural codes in a mouse model of Alzheimerâs disease, Graduate Research Fellowship Program (GRFP), Non-Invasive Methods to Drive Neural Activity with Millisecond Precision and to Recruit the Brain’s Immune Cells, G8557239431, Training In Systems And Integrative Biology Neuroscience