Work

LIF-ting ferroptosis to improve liver cancer therapy

Year: 2022

Type: article

Abstract: The liver is the largest internal organ that has vital roles in many processes, including digestion, detoxification, immunity, metabolism, blood clotting, and iron storage.It is susceptible to many pathological conditions that result in liver diseases.Liver cancer, ranking sixth in cancer incidence, is the fourth most common cause of cancer-related death worldwide and is the second most lethal cancer after pancreatic cancer. 1 The 5-year survival rate is 18%. 2 Unfortunately, liver cancer barely responds to chemotherapy and radiotherapy.At present, surgical resection and transplantation are recommended for patients with earlystage liver cancer, but for patients with advanced liver cancer and poor liver function, systemic therapy is the only Peer review under responsibility of Chongqing Medical

Source: Genes & Diseases

DOI: 10.1016/j.gendis.2022.02.013

Authors: Fan Yao, Yang Zhao, Li Ma

Institutions: Hubei University of Medicine, Huazhong Agricultural University, Taihe Hospital, The University of Texas MD Anderson Cancer Center, The University of Texas Health Science Center at Houston

Language: English

Topic: Ferroptosis and cancer prognosis

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500