Work

βENaC and ASIC2 associate in VSMCs to mediate pressure-induced constriction in the renal afferent arteriole

Year: 2022

Type: article

Abstract: Transmission of systemic blood pressure to delicate renal microvessels is a primary determinant of vascular injury in chronic kidney disease progression to end-stage renal disease. Here, we identified two degenerin family members, with an evolutionary link to mechanosensing, that interact biochemically and functionally to regulate systemic blood pressure and renal injury. Thus, degenerin proteins may serve as a target for the development of therapies to prevent or delay renal disease progression.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00003.2022

Authors: Yan Lu, David E. Stec, Ruisheng Liu, Michael Ryan, Heather A. Drummond

Institutions: University of Alabama at Birmingham, University of Mississippi Medical Center, University of South Florida, University of South Carolina

Language: English

Topic: Ion Channels and Receptors

Subfield: Sensory Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases