Work

Validation of spectrally encoded interferometric microscopy (SEIM) in finding ciliary beat frequency of human ex vivo upper airway tissue

Year: 2022

Type: conference-paper

Abstract: Mucociliary clearance facilitated by healthy cilia beating is crucial to normal upper airway function. Phase-contrast microscopy (PCM) is the current golden standard for measuring ciliary beat frequency (CBF) and has limitations. With PCM, one cannot appreciate how CBF varies across the complex landscape of the nasal vault and sinus tissues. With Spectrally encoded interferometric microscopy (SEIM), en face imaging of cilia can be achieved, providing insight into the changes in CBF across tissue surfaces. This study aims to validate the use of SEIM to quantify ciliary beat frequency across ex vivo upper airway tissue.

Source: Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology

DOI: 10.1117/12.2607390

Authors: Asher Park, Zhikai Zhu, Lidek Chou, Katelyn Dilley, Akarsh Lal, Edward C. Kuan, Zhongping Chen, Brian J. F. Wong

Institutions: Beckman Laser Institute and Medical Clinic, University of California, Irvine

Language: English

Topic: Optical Coherence Tomography Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4220801496

FWCI: 0.497

Cites: 18

Cited by: 1

Related to: 10