Work

Differential T-Cell Immunity to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in mRNA-1273– and BNT162b2-Vaccinated Individuals

Year: 2022

Type: article

Study design: Observational Study

Abstract: COVID-19 breakthrough cases among vaccinated individuals demonstrate the value of measuring long-term immunity to SARS-CoV-2 and its variants. We demonstrate that anti-spike T-cell responses and IgG antibody levels are maintained but decrease over time and are lower in BNT162b2- versus mRNA-1273-vaccinated individuals. T-cell responses to the variants are relatively unaffected.

Source: Clinical Infectious Diseases

DOI: 10.1093/cid/ciac201

Authors: Kathleen M E Gallagher, Mark B Leick, Rebecca C Larson, Trisha R Berger, Katelin Katsis, Jennifer Y Yam, Marcela V Maus

Institutions: Harvard University, Massachusetts General Hospital

Language: English

Topic: SARS-CoV-2 and COVID-19 Research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases

Awards: Training in Transplantation Biology, Efficacy and immune effects of anakinra prophylaxis for neurologic toxicity and cytokine release syndrome in patients with lymphoma receiving axicabtagene ciloleucel, Novel CAR T cell engineering strategies for effective eradication of solid and liquid tumors, Understanding and manipulating programmed cell death (PCD) pathways to facilitate lymphoid tumor killing by CAR T cells

OpenAlex ID: W4220905300

FWCI: 0.851

Cites: 14

Cited by: 7

Related to: 10