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The changing role of natural killer cells in cancer metastasis

Year: 2022
Type: review
Abstract: Natural killer (NK) cells are innate immune cells that are critical to the body's antitumor and antimetastatic defense. As such, novel therapies are being developed to utilize NK cells as part of a next generation of immunotherapies to treat patients with metastatic disease. Therefore, it is essential for us to examine how metastatic cancer cells and NK cells interact with each other throughout the metastatic cascade. In this Review, we highlight the recent body of work that has begun to answer these questions. We explore how the unique biology of cancer cells at each stage of metastasis alters fundamental NK cell biology, including how cancer cells can evade immunosurveillance and co-opt NK cells into cells that promote metastasis. We also discuss the translational potential of this knowledge.
DOI: 10.1172/jci143762
Institutions: Harold C. Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Johns Hopkins University, Johns Hopkins Medicine, Sidney Kimmel Cancer Center, Sidney Kimmel Comprehensive Cancer Center
Language: English
Subfield: Immunology
Open Access status: gold
Estimated APC paid: $5,200
Funders: Conquer Cancer Foundation, Breast Cancer Research Foundation, METAvivor, Metastatic Breast Cancer Network, Jayne Koskinas Ted Giovanis Foundation for Health and Policy, National Institutes of Health, National Cancer Institute
OpenAlex ID: W4220886948
FWCI: 2.292
Cites: 152
Cited by: 99
Related to: 10