Year: 2022
Type: review
Abstract: Tuberoinfundibular peptide of 39 residues (TIP39) acts via its endogenous class B G-protein coupled receptorthe parathyroid hormone 2 receptor (PTH2R). Hence, it is also known as parathyroid hormone 2. The peptide is expressed in the brain by a small number of neurons with a highly restricted distribution, which in turn project to a large number of brain regions that contain PTH2R. This peptide neuromodulator system has been extensively investigated over the past 20 years including its behavioural actions, such as its role in the control of nociception, fear and fear incubation, anxiety and depression-like behaviours, and maternal and social behaviours. It also influences thermoregulation and potentially auditory responses. TIP39 probably exerts direct effect on the neuronal networks controlling these behaviours based on the localization of PTH2R and local TIP39 actions. In addition, TIP39 also affects the secretion of several hypothalamic hormones providing the basis for indirect behavioural actions. Recently developed experimental tools have stimulated further behavioural investigations, and novel results obtained are discussed in this review.
Source: Journal of Neuroendocrinology
DOI: 10.1111/jne.13130
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,000
Funders: Semmelweis Egyetem, Gedeon Richter, Hungarian Scientific Research Fund, Eötvös Loránd Tudományegyetem, Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, National Institutes of Health, Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, National Research, Development and Innovation Office, National Institute of Mental Health
Awards: G1295621590, G134384773, G1348732877, G1602201056, G2009008446, G2029653815, G208526422, G2104806595, G2190636616, G2337539188, G2519277827, G2744728761, G2931706028, G2953162778, G298428782, Peptide Receptor Systems, G3146178709, G3463726684, G3539351221, G3743470659, G3942366215, G4111999775, G4291881689, G4562516941, G4712338446, G4789604680, G50699739, G5418648779, Peptide Receptor Systems, G6421238077, G6771105511, G7015593406, G7269143174, G7581414363, G7596933463, G7694217703, G785787759, G8714164205, G8797485977, G8880721597, Systems Neuroscience Imaging Resource
OpenAlex ID: W4220936422